Biological evaluation of substance P antagonists
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چکیده
منابع مشابه
Effects of substance P and substance P antagonists on rat salivary secretion.
The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7.9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7.9, Leu11]-substance P, but not by [D-Pro2, D-Trp7,9]-substance P. The profiles of protein...
متن کاملMast cell production of TNF-alpha induced by substance P evidence for a modulatory role of substance P-antagonists.
Unregulated increasing of Tumor necrosis factor-alpha (TNF-alpha) could be pathogenic in inflammatory diseases. The aim of this study was to investigate the anti-inflammatory role of the Substance P-antagonists (SPAs) through the inhibition of histamine release (HR) and TNF-alpha production from mast cell. Rat peritoneal mast cells (PMC) stimulated with Substance P (SP), in the presence of SPAs...
متن کاملPreparation and first biological evaluation of novel Re-188/Tc-99m peptide conjugates with substance-P.
INTRODUCTION New (188)Re and (99m)Tc peptide conjugates with substance- P (SP) were prepared and biologically evaluated. The radiopharmaceuticals have been labelled with the [M≡N](2+) (M=(99m)Tc, (188)Re) core using a combination of π-donor tridentate and π-acceptor monodentate ancillary ligands. METHODS The new radiopharmaceuticals have been prepared through a two-step reaction by simultaneo...
متن کاملAtrial natriuretic peptide antagonists: biological evaluation and structural correlations.
A collection of analogues of atrial natriuretic peptide (ANP) were screened for their ability to inhibit ANP-induced cGMP stimulation. The antagonists revealed through this screen are structurally related; almost all are substituted at either aspartate-13 or phenylalanine-26. This tendency is consistent throughout several families of small ANP analogues, suggesting that these two amino acid res...
متن کاملAssessment of antidepressant and anxiolytic properties of NK1 antagonists and substance P in Wistar Kyoto rats.
In an attempt to explore the involvement of substance P in depression and anxiety and its' potential therapeutic effects, we measured basal plasma and hypothalamic levels of substance P in a well-studied animal model of depression--adult male Wistar Kyoto (WKY) rats and their controls, Wistar rats. We also studied the influence of a substance P receptor (NK1) antagonist (SPA) on "anxiety-like" ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1984
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1984.tb16506.x